News nº 26 | Fevereiro/Março 2012
Investigação e Formação Avançada
Publicações Científicas

Faculdade de Medicina da Universidade de Lisboa / Hospital de Santa Maria / Instituto de Medicina Molecular

A Newsletter pretende, neste espaço, dar aos seus leitores uma perspectiva ampla da produção científica realizada na FMUL / HSM / IMM.

Inclui apenas artigos originais e revisões. 
Novembro 2011 / Janeiro 2012

Herrera Federico; Outeiro Tiago Fleming. a-Synuclein modifies huntingtin aggregation in living cells. FEBS LETTERS Volume: 586 Issue: 1 Pages: 7-12 DOI: 10.1016/j.febslet.2011.11.019 Published: JAN 2 2012
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Mendes J. J.; Marques-Costa A.; Vilela C.; et al. Clinical and bacteriological survey of diabetic foot infections in Lisbon. DIABETES RESEARCH AND CLINICAL PRACTICE Volume: 95 Issue: 1 Pages: 153-161 DOI: 10.1016/j.diabres.2011.10.001 Published: JAN 2012
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Navalho Márcio; Resende Catarina; Rodrigues Ana Maria; et al. Dynamic contrast-enhanced 3-T magnetic resonance imaging: a method for quantifying disease activity in early polyarthritis. SKELETAL RADIOLOGY Volume: 41 Issue: 1 Pages: 51-59 DOI: 10.1007/s00256-011-1112-8 Published: JAN 2012
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Chan Lai Y.; Gunasekera Sunithi; Henriques Sónia T.; et al. Engineering pro-angiogenic peptides using stable, disulfide-rich cyclic scaffolds. BLOOD Volume: 118 Issue: 25 Pages: 6709-6717 DOI: 10.1182/blood-2011-06-359141 Published: DEC 15 2011
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Ramalhete Cátia; da Cruz Filipa P.; Lopes Dinora; et al. Triterpenoids as inhibitors of erythrocytic and liver stages of Plasmodium infections. BIOORGANIC & MEDICINAL CHEMISTRY Volume: 19 Issue: 24 Pages: 7474-7481 DOI: 10.1016/j.bmc.2011.10.044 Published: DEC 15 2011
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Morais Goreti Ribeiro; Miranda Hugo Vicente; Santos Isabel C.; et al.
Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes
BIOORGANIC & MEDICINAL CHEMISTRY Volume: 19 Issue: 24 Pages: 7698-7710 DOI: 10.1016/j.bmc.2011.09.065 Published: DEC 15 2011
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Alonso-Perez Elisa; Suarez-Gestal Marian; Calaza Manuel; et al.
Association of Systemic Lupus Erythematosus Clinical Features with European Population Genetic Substructure Group Author(s): European Consortium SLE DNA
PLOS ONE Volume: 6 Issue: 12 Article Number: e29033 DOI: 10.1371/journal.pone.0029033 Published: DEC 14 2011
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Melo Manuel N.; Ferre Rafael; Feliu Lídia; et al. Prediction of Antibacterial Activity from Physicochemical Properties of Antimicrobial Peptides Source: PLOS ONE Volume: 6 Issue: 12 Article Number: e28549 DOI: 10.1371/journal.pone.0028549 Published: DEC 14 2011
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Almeida Celso; Kehraus Stefan; Prudencio Miguel; et al. Marilones A-C, phthalides from the sponge-derived fungus Stachylidium sp. BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY Volume: 7 Pages: 1636-1642 DOI: 10.3762/bjoc.7.192 Published: DEC 5 2011
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Ha Ngoc-Han; Nair Vasudha S.; Reddy Divijendra Natha Sirigiri; et al. Lactoferrin-Endothelin-1 Axis Contributes to the Development and Invasiveness of Triple-Negative Breast Cancer Phenotypes CANCER RESEARCH Volume: 71 Issue: 23 Pages: 7259-7269 DOI: 10.1158/0008-5472.CAN-11-1143 Published: DEC 1 2011
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Melo Graça; Maroco João; de Mendonça Alexandre. Influence of personality on caregiver's burden, depression and distress related to the BPSD. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Volume: 26 Issue: 12 Pages: 1275-1282 DOI: 10.1002/gps.2677 Published: DEC 2011
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Goetz Christopher G.; Stebbins Glenn T.; Theeuwes Ad; et al. Temporal stability of the Unified Dyskinesia Rating Scale. MOVEMENT DISORDERS Volume: 26 Issue: 14 Pages: 2556-2559 DOI: 10.1002/mds.23931 Published: DEC 2011
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Soeiro-de-Souza Márcio Gerhardt; Dias Vasco Videira; Bio Danielle Soares; et al. Creativity and executive function across manic, mixed and depressive episodes in bipolar I disorder. JOURNAL OF AFFECTIVE DISORDERS Volume: 135 Issue: 1-3 Pages: 292-297 DOI: 10.1016/j.jad.2011.06.024 Published: DEC 2011
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De Luca G.; Bellandi F.; Huber K.; et al. Early glycoprotein IIb-IIIa inhibitors in primary angioplasty-abciximab long-term results (EGYPT-ALT) cooperation: individual patient's data meta-analysis. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Volume: 9 Issue: 12 Pages: 2361-2370 DOI: 10.1111/j.1538-7836.2011.04513.x Published: DEC 2011

Caramalho I.; Rodrigues-Duarte L.; Perez A.; et al. Regulatory T cells Contribute to Diabetes Protection in Lipopolysaccharide-Treated Non-Obese Diabetic Mice
SCANDINAVIAN JOURNAL OF IMMUNOLOGY Volume: 74 Issue: 6 Pages: 585-595 DOI: 10.1111/j.1365-3083.2011.02627.x Published: DEC 2011

Martins A. P.; Lopes P. A.; Costa A. S. H.; et al. Differential mesenteric fat deposition in bovines fed on silage or concentrate is independent of glycerol membrane permeability. ANIMAL Volume: 5 Issue: 12 Pages: 1949-1956 DOI: 10.1017/S1751731111001091 Published: DEC 2011
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Coleman Robert; Costa Luis; Saad Fred; et al. Consensus on the utility of bone markers in the malignant bone disease setting. CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY Volume: 80 Issue: 3 Pages: 411-432 DOI: 10.1016/j.critrevonc.2011.02.005 Published: DEC 2011
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Nunes-Cabaco Helena; Caramalho Iris; Sepúlveda Nuno; et al. Differentiation of human thymic regulatory T cells at the double positive stage. EUROPEAN JOURNAL OF IMMUNOLOGY Volume: 41 Issue: 12 Pages: 3604-3614 DOI: 10.1002/eji.201141614 Published: DEC 2011
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Portugal Silvia; Drakesmith Hal; Mota Maria M. Superinfection in malaria: Plasmodium shows its iron will. EMBO REPORTS Volume: 12 Issue: 12 Pages: 1233-1242 DOI: 10.1038/embor.2011.213 Published: DEC 2011

Fonseca Ana Catarina; Geraldes Ruth; Pires Joana; et al. Improvement of sleep architecture in the follow up of a patient with bilateral paramedian thalamic stroke.
CLINICAL NEUROLOGY AND NEUROSURGERY Volume: 113 Issue: 10 Pages: 911-913 DOI: 10.1016/j.clineuro.2011.05.003 Published: DEC 2011
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Lopes José António; Melo Maria João; Viegas Ana; et al. Acute kidney injury in hospitalized HIV-infected patients: a cohort analysis. NEPHROLOGY DIALYSIS TRANSPLANTATION Volume: 26 Issue: 12 Pages: 3888-U671 DOI: 10.1093/ndt/gfr192 Published: DEC 2011

Paiva Teresa; Bugalho Paulo; Bentes Carla. Dreaming and cognition in patients with frontotemporal dysfunction. CONSCIOUSNESS AND COGNITION Volume: 20 Issue: 4 Special Issue: SI Pages: 1027-1035 DOI: 10.1016/j.concog.2011.06.008 Published: DEC 2011
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Esteves Teresa; Marques Fernanda; Paulo António; et al. Nuclear targeting with cell-specific multifunctional tricarbonyl M(I) (M is Re, (99m)Tc) complexes: synthesis, characterization, and cell studies. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY Volume: 16 Issue: 8 Pages: 1141-1153 DOI: 10.1007/s00775-011-0803-x Published: DEC 2011
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Pereira Ana L.; Martins Madalena; Margarida Oliveira M.; et al. Morphological and genetic diversity of the family Azollaceae inferred from vegetative characters and RAPD markers. PLANT SYSTEMATICS AND EVOLUTION Volume: 297 Issue: 3-4 Pages: 213-226 DOI: 10.1007/s00606-011-0509-0 Published: DEC 2011
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Barbosaa M.; Sousa A. B.; Medeira A.; et al. Clinical and molecular characterization of Diastrophic Dysplasia in the Portuguese population. CLINICAL GENETICS. Volume: 80 Issue: 6 Pages: 550-557 DOI: 10.1111/j.1399-0004.2010.01595.x Published: DEC 2011 

Pugdahl Kirsten; Fuglsang-Frederiksen Anders; Tankisi Hatice; et al. Impact of medical audit on electrodiagnostic medicine in polyneuropathy. CLINICAL NEUROPHYSIOLOGY Volume: 122 Issue: 12 Pages: 2523-2529 DOI: 10.1016/j.clinph.2011.05.018 Published: DEC 2011
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Geiger Jennifer A.; Carvalho Lara; Campos Isabel; et al. Hole-in-One Mutant Phenotypes Link EGFR/ERK Signaling to Epithelial Tissue Repair in Drosophila
PLOS ONE Volume: 6 Issue: 11 Article Number: e28349 DOI: 10.1371/journal.pone.0028349 Published: NOV 29 2011
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Vaz Sandra H.; Jorgensen Trine N.; Cristovao-Ferreira Sofia; et al. Brain-derived Neurotrophic Factor (BDNF) Enhances GABA Transport by Modulating the Trafficking of GABA Transporter-1 (GAT-1) from the Plasma Membrane of Rat Cortical Astrocytes. JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 286 Issue: 47 Pages: 40464-40476 DOI: 10.1074/jbc.M111.232009 Published: NOV 25 2011

Sando Lillian; Henriques Sonia Troeira; Foley Fiona; et al. A Synthetic Mirror Image of Kalata B1 Reveals that Cyclotide Activity Is Independent of a Protein Receptor.
CHEMBIOCHEM Volume: 12 Issue: 16 Pages: 2456-2462 DOI: 10.1002/cbic.201100450 Published: NOV 4 2011
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Cristovão-Ferreira Sofia; Navarro Gemma; Brugarolas Marc; et al. Modulation of GABA Transport by Adenosine A(1)R-A(2A)R Heteromers, Which Are Coupled to Both G(s)- and G(i/o)-Proteins. JOURNAL OF NEUROSCIENCE Volume: 31 Issue: 44 Pages: 15629-15639 DOI: 10.1523/JNEUROSCI.2526-11.2011 Published: NOV 2 2011

Valadas Anabela; Coelho Miguel; Mestre Tiago; et al. What motivates Parkinson's disease patients to enter clinical trials? PARKINSONISM & RELATED DISORDERS Volume: 17 Issue: 9 Pages: 667-671 DOI: 10.1016/j.parkreldis.2011.05.023 Published: NOV 2011
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Mishra N. K.; Ahmed N.; Davalos A.; et al. Thrombolysis outcomes in acute ischemic stroke patients with prior stroke and diabetes mellitus. Group Author(s): SITS Collaborator; VISTA Collaborator. NEUROLOGY Volume: 77 Issue: 21 Pages: 1866-1872 DOI: 10.1212/WNL.0b013e318238ee42 Published: NOV 2011

Bugalho Paulo; Paiva Teresa. Dream features in the early stages of Parkinson's Disease. JOURNAL OF NEURAL TRANSMISSION. Volume: 118 Issue: 11 Pages: 1613-1619 DOI: 10.1007/s00702-011-0679-5 Published: NOV 2011
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Severiano Ana; Pinto Francisco R.; Ramirez Mário; et al. Adjusted Wallace Coefficient as a Measure of Congruence between Typing Methods. JOURNAL OF CLINICAL MICROBIOLOGY Volume: 49 Issue: 11 Pages: 3997-4000 DOI: 10.1128/JCM.00624-11 Published: NOV 2011

Bentes Carla; Costa João; Peralta Rita; et al. Dream recall frequency and content in patients with temporal lobe epilepsy. EPILEPSIA Volume: 52 Issue: 11 Pages: 2022-2027 DOI: 10.1111/j.1528-1167.2011.03290.x Published: NOV 2011

Rodrigues Margarida; de la Torre Beatriz G.; Radis-Baptista Gandhi; et al. Efficient Cellular Delivery of beta-Galactosidase Mediated by NrTPs, a New Family of Cell-Penetrating Peptides. BIOCONJUGATE CHEMISTRY Volume: 22 Issue: 11 Pages: 2339-2344 DOI: 10.1021/bc200421z Published: NOV 2011
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Wollenberg Ivonne; Agua-Doce Ana; Hernandez Andrea; et al. Regulation of the Germinal Center Reaction by Foxp3(+) Follicular Regulatory T Cells. JOURNAL OF IMMUNOLOGY Volume: 187 Issue: 9 Pages: 4553-4560 DOI: 10.4049/jimmunol.1101328 Published: NOV 1 2011
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Lopes J. A.; Jorge S. Acute kidney injury following HCT: incidence, risk factors and outcome. BONE MARROW TRANSPLANTATION Volume: 46 Issue: 11 Pages: 1399-1408 DOI: 10.1038/bmt.2011.46 Published: NOV 2011

Barbosa Filipe; Mota Catarina; Patrício Patrícia; et al. The relationship between alexithymia and psychological factors in systemic lupus erythematosus. COMPREHENSIVE PSYCHIATRY. Volume: 52 Issue: 6 Pages: 754-762 DOI: 10.1016/j.comppsych.2010.11.004 Published: NOV-DEC 2011
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Portugal Sílvia; Armitage Andrew E.; Newbold Chris I.; et al. Hepcidin in malaria superinfection: can findings be translated to humans? Reply. NATURE MEDICINE Volume: 17 Issue: 11 Pages: 1341-1342 DOI: 10.1038/nm.2511 Published: NOV 2011
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Travassos Ana Rita; Claes Lieve; Boey Lies; et al. Non-fragrance allergens in specific cosmetic products. CONTACT DERMATITIS. Volume: 65 Issue: 5 Pages: 276-285 DOI: 10.1111/j.1600-0536.2011.01968.x Published: NOV 2011

Góis Carlos; Barbosa Antonio; Ferro Ana; et al. The role of affective temperaments in metabolic control in patients with type 2 diabetes. JOURNAL OF AFFECTIVE DISORDERS Volume: 134 Issue: 1-3 Pages: 52-58 DOI: 10.1016/j.jad.2011.05.021 Published: NOV 2011
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Carilho Rita; de Carvalho Mamede; Kuehl Ute; et al. Erythropoietin and amyotrophic lateral sclerosis: Plasma level determination. AMYOTROPHIC LATERAL SCLEROSIS Volume: 12 Issue: 6 Pages: 439-443 DOI: 10.3109/17482968.2011.584881 Published: NOV 2011

Haraoui Boulos; Smolen Josef S.; Aletaha Daniel; et al. Treating Rheumatoid Arthritis to Target: multinational recommendations assessment questionnaire. Group Author(s): Treat Target Taskforce. ANNALS OF THE RHEUMATIC DISEASES Volume: 70 Issue: 11 Pages: 1999-2002 DOI: 10.1136/ard.2011.154179 Published: NOV 2011
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Dorigo Walter; Pulli Raffaele; Castelli Patrizio; et al. A multicenter comparison between autologous saphenous vein and heparin-bonded expanded polytetrafluoroethylene (ePTFE) graft in the treatment of critical limb ischemia in diabetics. Group Author(s): Propaten Italian Registry Grp. JOURNAL OF VASCULAR SURGERY Volume: 54 Issue: 5 Pages: 1332-1338 DOI: 10.1016/j.jvs.2011.05.046 Published: NOV 2011
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Guimarães D.; Santos J. P.; Carvalho M. L.; et al. Ultrasonic energy as a tool to overcome some drawbacks in the determination of lead in brain tissue and urine of rats. TALANTA Volume: 86 Pages: 442-446 DOI: 10.1016/j.talanta.2011.09.001 Published: OCT 30 2011
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Costa Sofia Santos; Falcão Celeste; Viveiros Miguel; et al. Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Staphylococcus aureus. BMC MICROBIOLOGY. Volume: 11 Article Number: 241 DOI: 10.1186/1471-2180-11-241 Published: OCT 27 2011
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Badiola Nahuai; de Oliveira Rita Machado; Herrera Federico; et al. Tau Enhances alpha-Synuclein Aggregation and Toxicity in Cellular Models of Synucleinopathy
PLOS ONE. Volume: 6 Issue: 10 Article Number: e26609 DOI: 10.1371/journal.pone.0026609 Published: OCT 24 2011
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Foxall Russell B.; Albuquerque Adriana S.; Soares Rui S.; et al. Memory and naive-like regulatory CD4(+) T cells expand during HIV-2 infection in direct association with CD4(+) T-cell depletion irrespectively of viremia. AIDS Volume: 25 Issue: 16 Pages: 1961-1970 DOI: 10.1097/QAD.0b013e32834b3554 Published: OCT 23 2011

Soriano Vincent; Grint Daniel; Monforte Antonella d'Armínio; et al. Hepatitis delta in HIV-infected individuals in Europe. AIDS Volume: 25 Issue: 16 Pages: 1987-1992 DOI: 10.1097/QAD.0b013e32834babb3 Published: OCT 23 2011
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Cascales Laura; Henriques Sonia T.; Kerr Markus C.; et al. Identification and Characterization of a New Family of Cell-penetrating Peptides: cyclic cell-penetrating peptides. JOURNAL OF BIOLOGICAL CHEMISTRY Volume: 286 Issue: 42 Pages: 36932-36943 DOI: 10.1074/jbc.M111.264424 Published: OCT 21 2011

Marques-Vidal Pedro; Paccaud Fred; Ravasco Paula. Ten-year trends in overweight and obesity in the adult Portuguese population, 1995 to 2005. BMC PUBLIC HEALTH Volume: 11 Article Number: 772 DOI: 10.1186/1471-2458-11-772 Published: OCT 7 2011
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Martins Madalena; Rosa Alexandra; Guedes Leonor C.; et al. Convergence of miRNA Expression Profiling, alpha-Synuclein Interacton and GWAS in Parkinson's Disease
PLOS ONE Volume: 6 Issue: 10 Article Number: e25443 DOI: 10.1371/journal.pone.0025443 Published: OCT 7 2011
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Seppi Klaus; Weintraub Daniel; Coelho Miguel; et al. The Movement Disorder Society Evidence-Based Medicine Review Update: Treatments for the Non-Motor Symptoms of Parkinson's Disease. MOVEMENT DISORDERS Volume: 26 Supplement: 3 Pages: S42-S80 DOI: 10.1002/mds.23884 Published: OCT 2011
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da Silva Sara Pereira; Resnick Elena; Lucas Mary; et al. Lymphoid Proliferations of Indeterminate Malignant Potential arising in Adults with Common Variable Immunodeficiency Disorders: Unusual Case Studies and Immunohistological Review in the Light of Possible Causative Events. JOURNAL OF CLINICAL IMMUNOLOGY. Volume: 31 Issue: 5 Pages: 784-791 DOI: 10.1007/s10875-011-9565-z Published: OCT 2011
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Cardoso B. A.; de Almeida S. F.; Laranjeira A. B. A.; et al. TAL1/SCL is downregulated upon histone deacetylase inhibition in T-cell acute lymphoblastic leukemia cells. LEUKEMIA. Volume: 25 Issue: 10 Pages: 1578-1586 DOI: 10.1038/leu.2011.140 Published: OCT 2011

Rodriguez Ana; Mota Maria M. The crucial role of hepatocyte growth factor receptor during liver-stage infection is not conserved among Plasmodium species reply.
NATURE MEDICINE. Volume: 17 Issue: 10 Pages: 1181-1181 DOI: 10.1038/nm.2487 Published: OCT 2011
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Borges-Costa João; Marques Tiago; Soares-Almeida Luís; et al. Progressive disseminated histoplasmosis as a presentation of AIDS in a patient from the Congo: the role of skin biopsy. TROPICAL DOCTOR. Volume: 41 Issue: 4 Pages: 251-252 DOI: 10.1258/td.2011.110140 Published: OCT 2011

Swinnen Erwin; Buettner Sabrina; Outeiro Tiago F.; et al. Aggresome formation and segregation of inclusions influence toxicity of alpha-synuclein and synphilin-1 in yeast.
BIOCHEMICAL SOCIETY TRANSACTIONS. Volume: 39 Pages: 1476-1481 DOI: 10.1042/BST0391476 Part: Part 5 Published: OCT 2011

Martins Sandra Bento; Rino José; Carvalho Teresa; et al. Spliceosome assembly is coupled to RNA polymerase II dynamics at the 3 ' end of human genes. NATURE STRUCTURAL & MOLECULAR BIOLOGY. Volume: 18 Issue: 10 Pages: 1115-U49 DOI: 10.1038/nsmb.2124 Published: OCT 2011

Caldeira Daniel; David Claudio; Sampaio Cristina. Rate vs rhythm control in patients with atrial fibrillation and heart failure: A systematic review and meta-analysis of randomised controlled trials. EUROPEAN JOURNAL OF INTERNAL MEDICINE. Volume: 22 Issue: 5 Pages: 448-455 DOI: 10.1016/j.ejim.2011.05.001 Published: OCT 2011
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Fonseca Ana Catarina; Matias Joaquim Sampaio; Pinho e Melo Teresa; et al. N-terminal probrain natriuretic peptide as a biomarker of cardioembolic stroke.
INTERNATIONAL JOURNAL OF STROKE. Volume: 6 Issue: 5 Pages: 398-403 DOI: 10.1111/j.1747-4949.2011.00606.x Published: OCT 2011

Ferro José M.; Crassard Isabelle; Coutinho Jonathan M.; et al. Decompressive Surgery in Cerebrovenous Thrombosis A Multicenter Registry and a Systematic Review of Individual Patient Data. Group Author(s): Second Int Study Cerebral Vein
Source: STROKE Volume: 42 Issue: 10 Pages: 2825-2831 DOI: 10.1161/STROKEAHA.111.615393 Published: OCT 2011

Capela Rita; Cabal Ghislain G.; Rosenthal Philip J.; et al. Design and Evaluation of Primaquine-Artemisinin Hybrids as a Multistage Antimalarial Strategy.
Source: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY Volume: 55 Issue: 10 Pages: 4698-4706 DOI: 10.1128/AAC.05133-11 Published: OCT 2011

Canas Fernando; Correll Christoph U.; Fagiolini Andrea; et al. Practical guidance for prescribing ziprasidone in acute manic or mixed episodes of bipolar I disorder. EXPERT OPINION ON PHARMACOTHERAPY Volume: 12 Issue: 14 Pages: 2245-2263 DOI: 10.1517/14656566.2011.605787 Published: OCT 2011

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Propriedade e Edição: Faculdade de Medicina da Universidade de Lisboa
Periodicidade: Mensal
Diretor: Prof. Doutor Fausto J. Pinto
Conselho Editorial: Prof. Doutor Fausto J. Pinto, Prof. Doutor Mamede de Carvalho, Profª. Doutora Ana Sebastião, Prof. Doutor António Vaz Carneiro, Prof. Doutor Miguel Castanho, Dr. Luis Pereira
Gestor de Informação: Ana Raquel Moreira
Equipa Editorial: Ana Cristina Mota, Ana Raquel Moreira, André Silva, Maria de Lurdes Barata, Rui Gomes, Sónia Barroso
Colaboração: Unidade de Relações Públicas e Comunicação - Bruno Moura
Conceção e Suporte Técnico: UTI 
Design e Implementação: Spirituc
Morada e Sede da Redação: Avenida Prof. Egas Moniz, 1649-028 Lisboa

Estatuto Editorial

Anotado na ERC